Group I Metabotropic Glutamate Receptor Signaling via G q/G 11 Secures the Induction of Long-Term Potentiation in the Hippocampal Area CA1
نویسندگان
چکیده
1Department of Physiology, Kanazawa University School of Medicine, Takara-machi, Kanazawa 920-8640, Japan, 2Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060-8635, Japan, 3Pharmakologisches Institut, Abteilung Molekulare Pharmakologie, Universität Heidelberg, 69120 Heidelberg, Germany, and 4Division of Biology, California Institute of Technology, Pasadena, California 91125
منابع مشابه
G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region.
Long-term potentiation (LTP) and depression (LTD) are potential cellular mechanisms involved in learning and memory. Group I metabotropic glutamate receptors (mGluR), which are linked to heterotrimeric G-proteins of the G(q) family (G(q) and G(11)), have been reported to facilitate both hippocampal LTP and LTD. To evaluate their functional role in synaptic plasticity, we studied LTD and LTP in ...
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